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Cisplatin Adverse Effects

Cisplatin Adverse Effects

Description

Cisplatin is an anticancer agent which is used in the treatment of various cancers of the bladder, male and female reproductive system. It should be used under the supervision of a qualified physician. Close monitoring of kidney function and blood cell count are necessary while receiving this medication.

Uses

  • Testicular Cancer:Cisplatin is used in the treatment of cancer of testicles, which produce the male sex hormones and sperm.
  • Ovarian Cancer:Cisplatin is used in the treatment of cancer that affects the ovaries.
  • Bladder cancer:Cisplatin is used in the treatment of bladder cancer, which is an organ that stores urine.

How to Take Cisplatin

Cisplatin is given through intravenous (IV, into a vein) infusion. The dose and schedule is determined by the person's size and type of cancer. You will be given intravenous fluids prior to receiving cisplatin. It can be given alone or with other drugs.

Dosages

Cisplatin comes as a liquid that is injected into a vein over six to eight hours in a hospital or medical facility.Your dosage will be based on your medical condition, weight, and response to the therapy.Infusions are typically given once every three to four weeks.

Overdose

Symptoms of a cisplatin overdose may include:

  • Dark-colored urine or reduced urination
  • Inability to hear
  • Pale-colored stools

Miss dose

If you miss a dose of cisplatin, call your doctor right away.

Adverse Effect

  • Nausea (76-100%)
  • Vomiting (76-100%)
  • Nephrotoxicity (28-36%)
  • Ototoxicity, especially in children (31%)
  • Myelosuppression (25-30%)
  • Anaphylaxis (1-20%)
  • Alopecia

Frequency Not Defined

  • Cerebral herniation
  • Encephalopathy
  • Leukoencephalopathy and reversible posterior leukoencephalopathy syndrome
  • Seizure
  • Peripheral neuropathy (dose and duration dependent)
  • Diarrhea
  • Electrolyte changes
  • Hyperuricemia
  • Hepatotoxicity
  • Local tissue irritation

Precaution

Irritant; injection site reactions may occur during administration; use extravasation precautionsAvoid aluminum needles/equipmentPediatric patients, hearing impairment, neuropathy, neuromuscular disease, with neurotoxic agents, with ototoxic agents, elderlyRisk of cumulative nephrotoxicity (exacerbated by aminoglycoside antibiotics); renal toxicit becomes more prolonged and severe with repeated courses; renal function must return to normal before administering another dose

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