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Chlorambucil For Cats

chlorambucil for cats

Chlorambucil

Chlorambucil can produce a number of different side effects. The most common of these side effects include vomiting, diarrhea, loss of appetite, loss of hair (with delayed re-growth), tremors, seizures, and liver and kidney enzyme imbalances.

Effects of Chlorambucil

Chlorambucil can produce a number of different side effects. The most common of these side effects include vomiting, diarrhea, loss of appetite, loss of hair (with delayed re-growth), tremors, seizures, and liver and kidney enzyme imbalances. Other, more serious side effects are also possible, including bone marrow suppression, anemia, gastro-intestinal tract damage, kidney disease, lung disease, kidney damage, liver damage, and irreversible infertility in males.

How It Works

 Chlorambucil works by forming a strong bond with nucleic acid, making it impossible for DNA to properly divide and replicate. This makes it impossible for cancer cells and other cells to replicate. It also suppressed antibody production with this method.

Do I have to take special precautions?

Generally wearing gloves when giving the dose, and regular, thorough hygiene and hand washing are adequate and the normal precautions. Some vets warn against touching urine, feces, saliva; others don’t even tell you to wear gloves when giving the dose. But who among us gets poop or urine on our hands and doesn’t wash up right away? Of course, if you are immune compromised yourself, you may need to take extra precautions. Please discuss with your vet.

Dosage and Administration

The dosage and method of administration for Chlorambucil can only be determined by the animal’s treating veterinarian.  It is very important to keep the medication out of reach of children. Additionally, you should avoid contact with your pet’s urine, feces, saliva, or vomit for 48 hours after each dose.

Storage Information

Store in a tightly sealed container in a refrigerator. Additionally, as with any medication, keep out of children’s reach.

Missed Dose?

 If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Drug Interactions

Chlorambucil should be used with caution with other myelosuppressive or immunosuppressive drugs due to additive bone marrow suppression or increased risk of infection.

Overdose

Overdose may cause seizures and pancytopenia. Gastric emptying should be considered depending on the patient's neurologic status. Blood component therapy may be warranted based on the degree of pancytopenia.

What should I do if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

Keep this medicine out of reach of children and pets.

Store this medicine in a tight, light resistant container in the refrigerator at 2o to 8 oC.

SIDE EFFECTS

  • Damage to the gastro-intestinal tract
  • Low white blood cell count
  • Low platelet count
  • Bone marrow suppression
  • Blood cell deficiency
  • Damage to the kidneys
  • Damage to the liver
  • Kidney disease
  • Lung disease
  • Irreversible infertility in males
  • Hair loss in some dog breeds

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