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Cheap Nolvadex For Sale

Cheap Nolvadex For Sale

About Nolvadex:

 Nolvadex (Tamoxifen) is classified under the class of drugs known as selective estrogen receptor modulators or SERMs. This class of drugs have an estrogen antagonistic action on some sites in the body and have an opposite agonistic action on other sites. This partial agonist-antagonist effect and the selectivity of the antagonistic effect of Nolvadex has allowed its use in the treatment of breast cancer as well as the control of estrogen deficient symptoms in post menopausal women. Nolvadex has been found to be a miracle drug of sorts for patients suffering from breast cancer, and is generally used as adjuvant therapy in patients with estrogen receptor – positive breast cancer. It is indicated in patients who are pre-menopausal, though it has been found beneficial in post-menopausal patients. This is due to higher efficacy of aromatase inhibitors in this group of patients as compared to Nolvadex.

How Nolvadex Works: Nolvadex contains Tamoxifen, a selective estrogen receptor modulator. It has a potent antagonistic action on estrogen receptors in breast cancer cells, blood vessels and some peripheral tissues. However it has a partial agonistic action on estrogen receptors in the uterus, bone, liver and pituitary gland. Nolvadex is a prodrug, and gets converted to active metabolites in the body. On entering the cell, Nolvadex (Tamoxifen) binds with the estrogen receptor in the cell causing changes to DNA synthesis and prevents the action of estrogen on these cells. This action results in the tumour cells entering a dormant phase. Hence though Nolvadex does not directly kill cancer cells, it causes them to stop proliferating. It has been found to be effective only when estrogen receptors (ER) are present in higher proportions in the tumour. These tumours also have better prognosis..

Common effects of Nolvadex

  • hot flushes,
  • bleeding from the vagina,
  • pruritus vulvae,
  • weight gain,
  • fluid retention,
  • nausea,
  • headaches
  • and cramps.
  • More serious effects of Nolvadex are
  • hypercalcemia,
  • deep vein thrombosis,
  • hepatitis,
  • blood dyscrasias,
  • angioedema
  • and an increase in the risk of endometrial cancer.
  • What is the high risk group?
  • A high risk breast cancer group covers women after 35, women with bad family cancer background. These women should be supervised more frequently to timely start treatment.

How to take Novladex

After a patient gets cancer diagnosis, it is high recommended to be careful when taking it as the medication may interact with some other medicines a patient might take. These are the drugs you have to inform your doctor about if you take them before starting Nolvadex. Among these medications there are:

  • anticoagulants (Warfarin) – it increases the risks of bleeding;
  • cancer medicines of cytotoxic group (Cisplatin) – it increases the risks of bleeding;
  • Cinacalcet, Clobazam, Paroxetine, Duloxetine, Perphenazine, Rifampin, Thioridazine, Sertraline, Quinidine, Bupropion, Pimozide, Terbinafine, Fluoxetine, or Ticlopidine as they may decrease the effectiveness of Nolvadex;
  • Mitomycin C or Fluorouracil – increase the possible side effects of the medicine;
  • the effectiveness of the medication may be decreased by aromatase inhibitors.

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