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Carvedilol To Metoprolol Conversion

carvedilol to metoprolol conversion

What are Coreg and metoprolol tartrate?

Carvedilol is used to treat and congestive . It is related to (, ). Carvedilol blocks receptors of the adrenergic nervous system, which reduces the heart's rate and force of contraction and thereby reduces the work of the heart. Carvedilol also blocks adrenergic receptors on arteries and causes the arteries to relax and the blood pressure to fall. The drop in blood pressure further reduces the work of the heart since it is easier to pump blood against a lower pressure.

Metoprolol is a used to treat , heart , abnormal rhythms of the heart, and some neurologic conditions. Other beta-adrenergic blockers include propanolol (, , ), (), and (). Metoprolol is also used to treat congestive heart failure and (heart ) related to . Other uses for metoprolol include , , and the treatment of certain types of .

What is the dosage of Coreg vs. metoprolol tartrate?

  • Carvedilol tablets are usually given twice daily. For high blood pressure, the dose is 6.25 mg twice daily to a maximum of 25 mg twice daily.
  • For congestive heart failure, the dose is 3.25 mg twice daily to a maximum of 25 mg twice daily. A maximum dose of 50 mg twice daily has been used in persons weighing more than 85 kg (187 pounds).
  • Carvedilol should be taken with food to slow its absorption and reduce the occurrence of when rising from a sitting or sleeping position (). Stopping and changing doses of carvedilol should be done under the direction of a physician since sudden changes in dose can result in serious cardiac complications such as arrhythmias.
  • The dose range for treating heart failure or high blood pressure with extended release capsules is 10 to 80 mg once daily.

What is the difference between Coreg and metoprolol tartrate?

  • and tartrate are beta-adrenergic blocking agents () used to treat () and .
  • Brand names for carvedilol include and Coreg CR. Brand names for metoprolol tartrate include and .
  • Side effects of carvedilol and metoprolol tartrate that are similar include , decreased heart rate, and .
  • Side effects of carvedilol that are different from metoprolol tartrate include , (fluid accumulation), irregular heart rhythm, vision problems, and (a rapid decrease in when going from the seated to the standing position that causes lightheadedness and/or ).
  • Side effects of metoprolol tartrate that are different from carvedilol include abdominal cramps, extremities, , and or .

What are the side effects of Coreg and metoprolol tartrate?

  • The most common side effects of carvedilol are:
  • edema (fluid accumulation),
  • decreased heart rate,
  • and
  • postural (a rapid decrease in blood pressure when going from the seated to the standing position that causes lightheadedness and/or ).
  • Taking carvedilol with food minimizes the risk of postural .
  • Other common side effects of carvedilol are irregular heart rhythm, and abnormalities of vision.
  • Carvedilol should be used cautiously in patients who use diuretics or who are elderly or have , , , ,Prinzmetal's variant (angina at rest), or .

Metoprolol Tartrate

Metoprolol is generally well tolerated. Side effects inclu

  • abdominal cramps,
  • dreaming,
  • lightheadedness,
  • cold extremities,
  • shortness of breath or wheezing.
  • Possible serious adverse effects include
  • slow heart rate,
  • Raynaud's phenomenon,
  • increased .
  • Metoprolol can aggravate difficulties in patients with , , or .

WARNING

In patients with existing slow heart rates (bradycardias) and heart blocks (defects in the electrical conduction of the heart), metoprolol can cause dangerously slow heart rates, and even . Metoprolol reduces the force of heart muscle contraction and can aggravate symptoms of heart failure. In patients with , abruptly stopping metoprolol can suddenly worsen angina, and occasionally precipitate . If it is necessary to discontinue metoprolol, its dosage should be reduced gradually over several weeks.

Initiation of high-dose extended release metoprolol in patients undergoing non-cardiac surgery is associated with bradycardia (slow heart rate), , , and death. However, long-term therapy with metoprolol should not be routinely withdrawn prior to major surgery. Impaired ability of the heart to respond to reflex adrenergic stimuli may increase the risks of general anesthesia and surgery.

Metoprolol

Metoprolol should be taken before meals or at bedtime.

The dose for treating is 100-450 mg daily in single or divided doses.

 

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