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Carvedilol Contraindications

carvedilol contraindication

Contraindication

According to the FDA, carvedilol should not be used in people with bronchial asthma or bronchospastic conditions. It should not be used in people with second- or third-degree AV block, sick sinus syndrome, severe bradycardia (unless a permanent pacemaker is in place), or a decompensated heart condition. People with severe hepatic impairment are also advised to not take carvedilol.[8]

Mechanism of action

Carvedilol is both a non-selective beta adrenergic receptor blocker (β1, β2) and an alpha adrenergic receptor blocker (α1). The S(-) enantiomer accounts for the beta blocking activity whereas the S(-) and R(+) enantiomer have alpha blocking activity.[1]

Caredilol reversibly binds to beta adrenergic receptors on cardiac myocytes. Inhibition of these receptors prevents a response to the sympathetic nervous system, leading to decreased heart rate and contractility. This action is beneficial in heart failure patients where the sympathetic nervous system is activated as a compensatory mechanism.[9]

Carvedilol blockade of α1 receptors causes vasodilation of blood vessels. This inhibition leads to decreased peripheral vascular resistance and an antihypertensive effect. There is no reflex tachycardia response due to carvedilol blockade of β1 receptors on the heart.[10]

Who should not take Carvedilol?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:

Conditions:

  • Diabetes
  • Type of Angina Where Chest Pain Occurs at Rest
  • Complete Heart Block
  • Second Degree Atrioventricular Heart Block
  • Sick Sinus Syndrome
  • Sinus Bradycardia
  • Peripheral Vascular Disease
  • abnormally low blood pressure
  • Chronic Bronchitis
  • Emphysema
  • asthma
  • severe liver disease
  • Blood Circulation Failure due to Serious Heart Condition

Warnings and Precautions

  • There is a risk of myocardial infarction in the event of a sudden cessation of therapy, so it may only be discontinued gradually.
  • Before anesthesia, the doctor should be informed about the intake.
  • Diabetics should check their blood sugar levels frequently, and the signs of hypoglycaemia can no longer be recognized as such (obfuscation).
  • Contact lens wearers should keep in mind that lessening of tears may occur.
  • Regular medical checks are required. Treatment should be given to an experienced physician (internist, cardiologist).
  • At baseline, worsening of the heart (especially increased fluid retention) is possible.
  • If the heartbeat slows down, the doctor should reduce the dose.
  • The drug is on the Doping List and should not be used during sports competitions.
  • The ability to drive or operate machinery may be impaired. This applies to a greater extent at the beginning of treatment and in conjunction with alcohol.
  • Sometimes medications release allergic reactions.
  • If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.

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