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Carboplatin Vs Cisplatin

Carboplatin Vs Cisplatin

Description

  • Cisplatin and carboplatin, represent some of the most active cytotoxic agents and are the backbone of most chemotherapeutic regimens.
  • Despite their relative similarities in mechanisms of action, there are significant differences in efficacy and toxicity in various malignancies.
  • Carboplatin is a useful alternative in situations where cisplatin is contraindicated and this is not universally at the expense of efficacy.
  • De novo and acquired platinum resistance is inevitable and understanding the mechanisms of resistance is essential in improving outcomes.

Uses

Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.

Work

Chemotherapy is most effective at killing cells that are rapidly dividing. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. The "normal" cells will grow back and be healthy but in the meantime, side effects occur. The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different parts of the body.

Side Effect

  • Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.
  • Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia, and/or bleeding. Nadir: Meaning low point, is the point in time between chemotherapy cycles in which you experience low blood counts.
  • Nadir: 18-23 days. Recovery: 39 days
  • Kidney toxicity. Effects on kidney function are dose related, observed 10-20 days after therapy, and are generally reversible.
  • Ototoxicity hearing loss, ringing in the ears.
  • Blood test abnormalities (low magnesium, low calcium, low potassium)

Precaution

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Cisplatin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking cisplatin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

Do not breast feed while taking cisplatin.

Tips

  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, eat small amounts of food frequently.
  • Try dry cereal, toast, or crackers, especially in the morning, to help curb nausea.
  • Maintaining a good fluid intake is very important to help to avoid kidney damage. Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
  • Wash your hands often.
  • To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
  • Use an electric razor and a soft toothbrush to minimize bleeding.
  • In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
  • Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing.
  • Get plenty of rest.
  • Maintain good nutrition.

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