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Calcipotriol 0.005 %Betamethasone 0.05%

Calcipotriol 0.005 %, betamethasone 0.05 %

Introduction

Topical corticosteroids including clobetasol propionate have been widely used in the treatment of psoriasis since the 1950s. Similar efficacy successes have been reported following 2 weeks of treatment with clobetasol propionate 0.05% (CP) spray or 4 weeks of treatment with calcipotriene 0.005%, betamethasone dipropionate 0.064% (C-BD) ointment in separate studies. Greater efficacy has been noted with clobetasol propionate 0.05% spray when used for 4 weeks compared with 2 weeks with an acceptable safety profile. Clobetasol propionate 0.05% spray and calcipotriene 0.005%, betamethasone dipropionate 0.064% ointment have not previously been directly compared for efficacy and safety in the same study.

Why is this medication prescribed?

Calcipotriene is used to treat psoriasis (a skin disease in which red, scaly patches form due to increased production of skin cells on some areas of the body). Calcipotriene is in a class of medications called synthetic vitamin D3 derivatives. It works by slowing the excessive production of skin cells.

How should this medicine be used?

Calcipotriene comes as a cream to apply to the skin and as a solution (liquid) to apply to the scalp. The cream and solution are usually applied two times a day. Use calcipotriene at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use calcipotriene exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Calcipotriene controls psoriasis but does not cure it. You may see some improvement in your condition after 2 weeks, but it may take up to 8 weeks before you feel the full benefit of calcipotriene.

Do not apply calcipotriene cream to the face.

Calcipotriene solution may catch fire. Do not use this medication near heat or an open flame, such as a cigarette.

Warning!

This medicine is for external use on the skin only.

The ointment should be applied thinly and evenly to the affected area(s).

Do not apply the ointment to your face. Take care to avoid getting it on your face or in your eyes. Rinse your eyes with water if you accidentally get the ointment in your eyes and consult your doctor if your eyes get sore.

Wash your hands after applying the ointment, unless you are treating psoriasis on your hands.

Do not exceed the dose of this medicine recommended by your doctor or described in the leaflet provided with this medicine. Excessive use can lead to a rise in the calcium levels in the body and increases the chances of side effects from the corticosteroid (see below).

Consult your doctor if your skin becomes infected during treatment, as you may need to stop using this medicine and start treatment with antibiotics.

Side effects

Common (affect between 1 in 10 and 1 in 100 people)

  • Itching.
  • Rash.
  • Burning sensation of skin.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Skin pain or irritation in area of use.
  • Inflammation of the hair follicles (folliculitis).
  • Inflammation of the skin (dermatitis).
  • Reddening of skin.
  • Changes in skin pigmentation in area of use.
  • Worsening of psoriasis.

Conclusions

The results of this randomized 4-week comparative study are expected to provide further information to dermatologists considering treatment choices for psoriasis patients who are candidates for topical corticosteroid therapy

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