- Manufacturer : Cipla Ltd
- Equivalent Brands : Triomune
- Generic Brands : Stavudine / Lamivudine / Nevirapine
Triomune is an antiretroviral medication used in the management of HIV. It is recommended for HIV-infected adults. The medicine lowers the amount of HIV in the blood and keeps it at a low level. It plays a significant role in maintaining a healthy immune system to help fight infection. It is a combination drug containing three active components lamivudine, nevirapine, and stavudine. Lamivudine and stavudine belongs to the group of medicines known as nucleoside analogue. Nevirapine, the third active component of the medicine is a non-nucleoside reverse transcriptase inhibitor.
Both stavudine and lamivudine belong to the group of medication known as nucleoside analogs. Both antiretroviral agents work together by terminating the growth of the DNA chain and reverse transcriptase of HIV. On the other hand, nevirapine is a non-nucleoside reverse transcriptase inhibitor. It functions by directly inhibiting reverse transcriptase.
Triomune is used to slow down the progression of HIV infection. Its administration allows the number of CD4+ cells to increase and to help the defense system to recover and reduce the risk of spreading the disease.
Triomune tablets contain a combination of 3 antiretroviral drugs stavudine, lamivudine and nevirapine, which are effective only against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). These three drugs each work by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT) which is needed for the virus to be able to replicate.
Retroviruses convert RNA to DNA, which is then integrated into the DNA of infected immune cells so that the virus can replicate.
Nevirapine in Triomune tablets is a dipyridodiazepine derivative non-nucleoside reverse transcriptase inhibitor (NNRTI); nucleosides are the precursors to the building blocks of DNA and RNA.
Nevirapine in Triomune tablets acts by binding to a specific site on the RT enzyme, the enzyme's active site known as the NNRTI pocket, disrupting the catalytic site of the enzyme, and blocking its action in a manner that is noncompetitive with nucleosides.
Stavudine and lamivudine are both nucleoside analogue reverse transcriptase inhibitors (NRTI), which means that they block the action of RT by competing with one of the nucleosides needed to transcribe the viral RNA into DNA, becoming incorporated into the chain of newly synthesized viral DNA and preventing it from growing (chain termination).
Stavudine is an analogue of thymidine and lamivudine is an analogue of cytidine.
The combined action of the three antiiretroviral drugs in Triomune tablets prevents the integration of the virus into the DNA of the infected CD4+ immune cell by 2 different mechanisms, which inhibits the replication of HIV so that no more virus can be produced and this reduces the viral load (amount of virus).
Triomune 30 slows down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.
The Stavudine+Lamivudine+Nevirapine dosage may depend on different factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. The usual dose is one 30+150+200 mg tablet once in a day.
Swallow the tablet with glass full of water. Do not break or crush the tablet. Take the medicine with or without food, or ask your doctor in case of any confusion. HIV is usually treated with a combination of drugs. Always take the prescribed drugs as directed by your doctor in combination with other HIV drugs. The drug comes with a warning card that lists the symptoms of allergic reactions.
Taking the tablet at the same time each day will help you to avoid forgetting the dose. This should become a habit for you to take the tablet until the doctor tells you to stop the drug.
This drug controls the multiplication of HIV but does not cure the problem. Take the drug as long as your doctor recommends you to take it.
In case of any discomfort, immediately call the doctor and inform him about the possible side effects of over dosage. If the situation worsens then visit the nearest healthcare center or call the emergency helpline number.
In case of miss dose, skip the missed dose and take the next dose on the recommended time period. Do not double up the dose for the missed one.
Triomune (Stavudine+Lamivudine+Nevirapine) is an antiviral drug that prevents the human immunodeficiency virus (HIV) virus from multiplying in the body. This medication is used in the treatment of
HIV/AIDS. Triomune will however, not cure the body of HIV.
You should store your Triomune below 25°C in a cool dry place.