1. Buy Natdac 60mg Online
Natdac 60Mg Tablet is used in combination with other medications such as sofosbuvir, interferon and ribavirin for the treatment of hepatitis C infection.
On using this medication you may experience side effects such as nausea, headache, weakness, fatigue, breakdown of the red cell, diarrhoea, drowsiness, dizziness and skin rash. If your reactions persist or become worse over time seek the help of your health care provider right away.
2. How To Natdac 60mg Work?
Natdac 60mg Tablet is an antiviral medication. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.
3. What is Natdac 60mg Tablet?
Natdac tablets 60mg are used to treat chronic hepatitis C virus infection in adults as part of a combination therapy regimen with other antiviral medications as they are not effective if used as monotherapy. Hepatitis C is a disease of the liver caused by infection with the Hepatitis C virus (HCV) that is carried in the blood.
Infection is spread by direct contact with infected blood or blood products, such as intravenous injection of drugs using unsterilised needles, tattooing or body piercing using unsterile equipment, blood transfusion or received blood products using unscreened blood, organ transplant, healthcare needle stick injury.
Infection with HCV can result in acute disease or chronic disease. Although acute symptoms may not always appear, they can appear within a few weeks or up to 6 months after infection, ranging from mild to severe, and include abdominal pain, loss of appetite, dark coloured urine, grey coloured faeces, nausea, upset stomach, fatigue.
Acute HCV can result in jaundice, which causes yellowing of skin and the whites of the eyes. If the virus is not cleared from the body, which does occur spontaneously in a proportion of those infected, then they can develop symptoms of chronic HCV many years after the initial infection.
Chronic HCV infection causes inflammation of the liver and can lead to other more serious diseases such as liver fibrosis (early stages of liver damage and scarring) and cirrhosis (build-up of scar tissue), liver carcinoma and liver failure requiring liver transplant. Other parts of the body can be infected as the immune system produces antibodies to fight the infection and this can result in kidney failure and skin rash. HCV exists in different forms known as genotypes.
Genotype 1 is the most common type of HCV genotype and is also the most difficult to treat using other treatments. Natdac 60 is effective against genotypes 1, 3, and 4, but only in combination with sofosbuvir, another antiviral medication.
However, if the liver is badly damaged by cirrhosis Natdac 60 should also be used in combination with the antiviral ribavirin as part of a triple combination therapy regimen. A cure from HCV infection is defined as no more detectable virus in the blood, which persists for at least 12 weeks after treatment.
Natdac tablets 60mg in combination with other antiviral medications reduce the amount of virus in the blood and can even cure the disease.
4. How To Take Natdac 60mg Tablet?
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
5. Mechanism Action Of Natdac 60mg?
Natdac tablets 60mg contain daclatasvir, a direct-acting antiviral agent that is used to treat chronic HCV infection, in combination with sofosbuvir another antiviral medication. Daclatasvir in Natdac 60 inhibits the viral specific NS5A protein, which has no enzymatic activity but is essential for HCV RNA replication and post-replication assembly of the virus particle. It is highly effective at very low doses. Sofosbuvir that is used in combination with Natdac 60 targets a different stage in the viral replication cycle.
It is a direct-acting nucleotide analogue inhibitor that blocks the action of the HCV NS5B polymerase, an enzyme that is essential to viral replication, by being incorporated into HCV RNA by the action of NS5B polymerase, which causes chain termination of viral RNA synthesis thereby inhibiting viral replication. Daclatasvir in Natdac 60 works together with sofosbuvir to lower the amount of hepatitis C virus in the blood and may also lead to a cure of HCV infection over a number of weeks.
Ribavirin is a synthetic ribonucleic analogue and is incorporated into viral RNA blocking RNA synthesis; however, it does not have any antiviral activity when used alone. This antiviral drug is used in triple combination therapy with daclatasvir in Natdac 60 and sofosbuvir in those with liver cirrhosis.
6. Drug interaction of Natdac 60mg
Several medications interact with Natdac 60 and should either not be taken while you are taking Natdac 60 or only after discussion and instruction from your doctor:
Drugs that cause a serious reaction with Natdac 60: the antiarrhythmic amiodarone can cause severe bradycardia (slow heartbeat)
Drugs that affect Natdac 60: anticonvulsants like carbamazepine and phenytoin, the antibacterial rifampicin, some antivirals for HIV like atazanavir, St. John’s wort
Drugs that are affected by Natdac 60: digoxin for heart failure, rosuvastatin for high cholesterol.
7. Side Effects of Natdac 60mg
- Insomnia (difficulty in sleeping),
- Anemia (low number of red blood cells).
8. Warning And Precaution of Natdac 60mg tablet
You should not use Natdac 60 if you:
are allergic to daclatasvir or any ingredients in Natdac 60
are allergic to sofosbuvir that is used in combination with Natdac
are pregnant or are breastfeeding
have kidney or liver disease other than hepatitis C
have been infected with hepatitis B virus as treatment for HCV can increase replication of HBV and this should be monitored
are taking medicines that interact with Natdac 60, including the antiarrhythmic amiodarone, anticonvulsants like carbamazepine and phenytoin, the antibacterial rifampicin, digoxin for heart failure, some antivirals for HIV like atazanavir, St. John’s wort, rosuvastatin for high cholesterol.
9. Uses of Natdac 60mg
Natdac 60mg Tablet is used in the treatment of chronic hepatitis C virus (HCV) infection.
10. Storage of Natdac 60mg
You should store your Natdac 60 below 25°C in a cool dry place.