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Buy Itraconazol

Buy Itraconazol

Why is this medication prescribed?

Itraconazole capsules are used to treat fungal infections in the lungs that can spread throughout the body. Itraconazole capsules are also used to treat fungal infections of the fingernails. Itraconazole tablets and capsules are used to treat fungal infections of the toenails. Itraconazole oral solution (liquid) is used to treat yeast infections of the mouth and throat or of the esophagus (tube that connects the throat to the stomach). Itraconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

How should this medicine be used?

Itraconazole comes as a capsule, a tablet, and a solution (liquid) to take by mouth. If you are taking itraconazole to treat fungal infections in the lungs, the capsules are usually taken during or right after a full meal one or two times a day for at least 3 months. However, if you are taking itraconazole to treat a serious fungal infection in the lungs, the capsules may be taken with a meal three times a day for the first 3 days of treatment and then taken once or twice a day with a meal for at least 3 months. If you are taking itraconazole to treat fungal infections of the toenails (including or without fingernail infections), the capsules or tablets are usually taken once a day with a full meal for 12 weeks. If you are taking itraconazole to treat fungal infections of the fingernails only, the capsules are usually taken twice a day with a full meal for 1 week, skipped for 3 weeks, and then taken twice a day with a meal for a week. Itraconazole oral solution is usually taken on an empty stomach once or twice a day for 1 to 4 weeks or sometimes longer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take itraconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow itraconazole capsules whole; do not open, chew, or crush them.

Your doctor may tell you to take itraconazole capsules with a cola soft drink if you have certain medical conditions or are taking any of the following medications: cimetidine; famotidine (Pepcid); nizatidine (Axid); proton-pump inhibitors such as esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Zegerid), pantoprazole (Protonix), rabeprazole (AcipHex), or ranitidine (Zantac). Follow these directions carefully.

To take itraconazole oral solution for fungal infections of the mouth or throat, swish 10 milliliters (about 2 teaspoons) of the solution in your mouth for several seconds and swallow. Repeat if necessary to take your entire dose.

Mechanism of action

These compounds act by inhibiting the enzyme lanosterol 14- a demethylase in the cytochrome P-450 complex of fungi. The result is the inhibition of the conversion of lanosterol to ergosterol, with the consequent depletion of ergosterol, accumulation of precursors and a loss of integrity of the fungal membrane. 1 Imidazoles and, to varying degrees, triazoles, also interact with the P-450 complex of the human species, causing metabolic interferences with certain hormones or interactions with drugs metabolized under this system.

Contraindications and precautions

Contraindicated in cases of hypersensitivity to itraconazole, achlorhydria, hypochlorhydria, active alcoholism, liver or kidney dysfunction, during pregnancy and lactation. Administration is also contraindicated in patients taking terfenadine, cisapride or astemizole, as cardiac arrhythmias may occur. Ketoconazole increases plasma levels of itraconazole. Increases the effects of warfarin. Isoniazid, phenytoin and rifampicin reduce their plasma levels. Antacids, anticholinergics, antispasmodics and H 2 antagonists increase the stomach pH and decrease the absorption of itraconazole. Increases the effect of oral hypoglycemic agents.

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