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Buy Imatinib

Buy Imatinib

Imatinib is a type of biological therapy called a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that cells use to signal to each other to grow. They act as chemical messengers. There are a number of different tyrosine kinases and blocking them stops the cancer cells growing.

Imatinib (Glivec)

Find out what imatinib is, how you have it and other important information about taking imatinib.

Imatinib is a targeted cancer drug (biological therapy) and is also known by its brand name Glivec (pronounced glee-vec).

It is a treatment for many different types of cancer.

How it works

Imatinib is a type of biological therapy called a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that cells use to signal to each other to grow. They act as chemical messengers. There are a number of different tyrosine kinases and blocking them stops the cancer cells growing.

Imatinib targets different tyrosine kinases, depending on the type of cancer.

How you have it

You have imatinib as a tablet that you swallow whole, with a glass of water after food. If you can’t swallow the tablets, you can dissolve them in a glass of mineral water or apple juice. Drop the whole tablets into the fluid, and stir with a spoon until the tablets have broken up completely. Then drink the whole glassful.

Precautions

Before taking imatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, heart problems (such as heart failure), kidney disease, liver disease, removal of thyroid gland.

side effects

  • Headache
  • Fatigue
  • Joint pain
  • Indigestion (see heartburn)
  • Abdominal pain
  • Cough
  • Shortness of breath
  • Poor appetite
  • Constipation
  • Night sweats (see skin reactions)
  • Nose bleeds (see bleeding problems)
  • Weakness
  • Your fertility 

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Adverse Reactions

Edema (may be severe), nausea, vomiting, musculoskeletal pain, diarrhea, muscle cramps, rash (may be severe; eg, erythema multiforme, Stevens-Johnson syndrome), fatigue, abdominal pain, dizziness, blurred vision, somnolence, fever, headache, cough, arthralgia/myalgia, dyspnea, hypokalemia, night sweats, anorexia, pruritus, hemorrhage, anemia, neutropenia, thrombocytopenia, weight gain, renal or hepatotoxicity, immunosuppression, hypothyroidism; rare: severe CHF, LV dysfunction.

Gleevec Dosage

Gleevec is a pill that is taken either once or twice daily, depending on the dose.
Gleevec is different from traditional chemotherapy in that it is very selective. Traditional chemotherapy kills all cells that are dividing quickly. This is what causes so many of the side effects of traditional chemotherapy.

In addition to the cancer cells, this type of chemotherapy also kills many of the bodies normal cells. Gleevec is much more selective and as a result has fewer side effects. It was designed to block the activity of a mutant type of enzyme (an enzyme is a specific type of protein) that causes Chronic Myeloid Leukemia (CML). It is used in GIST because it also blocks KIT and PDGFRA.

Dose and Dose Concentrations

Patients metabolize drugs at different rates. This means that 2 patients taking the same dose can have different concentrations of the drug in their body. Documentation supplied to the FDA shows that drug concentrations can vary up to 40% between patients taking the same dose.

Other drugs can affect Gleevec drug concentrations. Gleevec is primarily metabolized by an enzyme in the liver known as P450 3A4, also known as CYP 3A4. Drugs that INDUCE CYP 3A4 can LOWER Gleevec drug concentrations. In extreme cases, this could cause Gleevec to become ineffective.

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