1. Buy Hepcvir L Tablet Online
Hepcvir L 90Mg/400Mg Tablet helps in the treatment of chronic hepatitis C (HCV). This drug is used in a combination with another drug, to prevent the spread of HCV throughout the body.
Hepcvir L 90Mg/400Mg Tablet is meant to be taken orally, either with food or without. Antacids containing magnesium or aluminum should not be consumed for a few hours after taking the drug. The drug should be taken regularly, preferably at a particular time each day. Try not to miss any doses.
2. How To Hepcvir L Work?
Hepcvir L 90mg/400mg Tablet is a combination of two antiviral medicines: Ledipasvir and Sofosbuvir. They work by lowering the amount of hepatitis C virus in the body and removing the virus from the blood over a period of time.
3. What is Hepcvir L Tablet?
Patients who have liver issues, or kidney problems and are undergoing dialysis, are not advised the use of Hepcvir L 90Mg/400Mg Tablet. Also inform your doctor about any other health issues you are suffering from and if you are taking any medicines to treat them.
Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase the key enzyme mediating HCV RNA replication.
The triphosphate form of sofosbuvir mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.
Hepcvir L 90Mg/400Mg Tablet may result in a few common side effects such as irritation, pain in the muscles, diarrhea, headache, cough, and problems with sleep. Side effects that are less common but may occur none the less are loss of appetite, discontentment, dizziness and problems with concentration. If these side effects persist or deteriorate, get in touch with your health care provider immediately.
4. How To Take Hepcvir L Tablet?
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hepcvir L 90mg/400mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
5. Mechanism Action Of Hepcvir L?
Hepcvir L tablets contain a fixed dose combination of two direct-acting antiviral agents, ledipasvir 90mg and sofosbuvir 400mg that are used to treat chronic HCV infection. Each drug targets a different stage in the viral replication cycle.
Ledipasvir in Hepcvir L tablets inhibits the viral specific NS5A protein, which has no enzymatic activity but is essential for HCV RNA replication and post-replication assembly of the virus particle (virion). It is highly effective at very low doses.
Sofosbuvir in Hepcvir L tablets is a direct-acting nucleotide analogue inhibitor that blocks the action of the HCV NS5B polymerase, an enzyme that is essential to viral replication.
It is a nucleotide prodrug that is converted to its active form, the uridine analog triphosphate (GS-461203), which is incorporated into HCV RNA by the action of NS5B polymerase.
This action of sofosbuvir in Hepcvir L tablets causes chain termination of viral RNA synthesis thereby inhibiting viral replication.
Ledipasvir and sofosbuvir in Hepcvir L tablets work together to lower the amount of hepatitis C virus in the blood and may also lead to a cure of HCV infection over a number of weeks.
6. Side Effects of Hepcvir L
In addition to its intended effect, Hepcvir L 90Mg/400Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
- Insomnia (difficulty in sleeping)
7. Warning And Precaution of Hepcvir L tablet
You should not use Hepcvir L tablets if you:
are allergic to ledipasvir or sofosbuvir or any ingredients in Hepcvir L
are pregnant or are breastfeeding
have kidney disease
have liver disease other than hepatitis C
are taking either ledipasvir or sofosbuvir separately
are taking medicines that interact with Hepcvir L, including the antiarrhythmic amiodarone, acid reducing drugs for reflux like antacids, cimetidine and omeprazole, digoxin for heart failure, anticonvulsants like carbamazepine and phenytoin, the antibacterial rifampicin, some antivirals for HIV like tenofovir, St. John’s wort, the statin Rosuvastatin for high cholesterol.
8. Uses of Hepcvir L
Ledipasvir and sofosbuvir is used for treating chronic hepatitis C virus (HCV) infection in certain patients. Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
It reduces the amount of HCV in the body by preventing the spread of the HCV within the body. Ledipasvir-sofosbuvir is a preferred regimen for initial treatment and retreatment of patients with genotypes 1, 4, 5, or 6 chronic hepatitis C infection.
9. Storage of Hepcvir L
Store below 30°C (86°F). Dispense in original container.