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Buy Febuxostat

Buy Febuxostat


Febuxostat, sold under the brand names Uloric and Febuday among others, is a medication used in the treatment of chronic gout and hyperuricemia. It inhibits xanthine oxidase, thus reducing production of uric acid in the body.

How to use Febuxostat Tablet

Read the Patient Information Leaflet if available from your pharmacist before you start taking febuxostat and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Febuxostat is not a pain reliever. Your doctor may prescribe medication (such as colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent/treat a gout attack during the first several months you are taking febuxostat. Continue to take your prescribed medicines for gout attacks as directed by your doctor.

What is febuxostat, and how does it work (mechanism of action)?

Febuxostat is a xanthine oxidase inhibitor used for treating gout caused by excessive levels of uric acid in the blood (hyperuricemia). Uric acid is formed from the breakdown of certain chemicals (purines) in the body. Hyperuricemia occurs when the body produces more uric acid than it can eliminate. The uric acid forms crystals in joints (gouty arthritis) and tissues, causing inflammation and pain. Elevated blood uric acid levels also can cause kidney disease and kidney stones.

Febuxostat prevents the production of uric acid by blocking the activity of the enzyme (xanthine oxidase) that converts purines to uric acid. Uric acid levels may fall to target treatment levels within two weeks. Febuxostat and allopurinol (Zyloprim) are similar in how they work, but the maximum dose of febuxostat is more effective in reducing uric acid levels. The FDA approved febuxostat in February 2009.

Side effects:

Febuxostat may rarely cause serious (possibly fatal) liver disease. It may also cause an increase in liver enzymes. Your doctor will order blood tests to measure these enzymes. Keep all medical/lab appointments. Tell your doctor right away if you develop symptoms of liver disease, including nausea that doesn't stop, stomach/abdominal pain, dark urine, yellowing eyes/skin.

Tell your doctor right away if you have any serious side effects, including: pink/bloody urine, painful urination.

A small number of people who took this medication had heart-related problems or stroke. However, it is not known if this medication caused these problems. Get medical help right away if you have any of these very serious side effects, including: weakness on one side of the body, sudden vision changes, confusion, chest/jaw/left arm pain, unusual sweating, signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

Important warnings

Gout flare-ups warning: You may have more gout flare-ups when you start taking febuxostat. You should continue taking this drug even if gout flare-ups occur. Your doctor may give you nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine to prevent flare-ups when you start febuxostat. The flare-ups may last up to 6 months.

Liver injury warning: Your doctor may do blood tests to check your liver function before you start this drug. This drug can also cause inaccurate liver function test results. This effect may make it difficult for your doctor to tell how this drug is affecting your liver. If you develop liver damage while taking this drug, your doctor may stop your treatment with this drug.