1. Buy Estramustine 140mg Capsules Online
Estramustine phosphate sodium, an antineoplastic agent, is an off-white powder readily soluble in water. Estramustine Capsules are white and opaque, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate, for oral administration. Each capsule also contains magnesium stearate, silicon dioxide, sodium lauryl sulfate, and talc. Gelatin capsule shells contain the following pigment: titanium dioxide.
2. How To Estramustine 140mg Work?
Estramustine belongs to the group of cancer-fighting medications known as antineoplastics. It is made up of 2 different types of medications joined together: mechlorethamine and estrogen. Mechlorethamine belongs to a group of medications known as alkylating agents. Estrogen is a female hormone. Estramustine is used to treat cancer of the prostate that has spread and is not responding to other treatments.
The mechlorethamine portion of estramustine prevents the growth of cancer by interfering with the genetic material DNA, which is necessary for reproduction of cells. After estramustine is broken down or metabolized by the body, estrogen is released. The estrogen component of estramustine slows down the growth of prostate cancer cells. This medication may need to be taken for several weeks or months in order to be effective.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
3. Side Effects of Estramustine 140mg
- breast tenderness or enlargement
- decreased interest in sex
- decreased sexual ability
- muscle weakness
- stomach upset
4. Warning of Estramustine 140mg Capsule
It has been shown that there is an increased risk of thrombosis, including fatal and nonfatal myocardial infarction, in men receiving estrogens for prostatic cancer.
Estramustine Capsules should be used with caution in patients with a history of thrombophlebitis, thrombosis, or thromboembolic disorders, especially if they were associated with estrogen therapy.
Caution should also be used in patients with cerebral vascular or coronary artery disease. Glucose Tolerance—Because glucose tolerance may be decreased, diabetic patients should be carefully observed while receiving Estramustine.
Elevated Blood Pressure—Because hypertension may occur, blood pressure should be monitored periodically.
5. Precaution of Estramustine 140mg Capsule
Fluid Retention. Exacerbation of preexisting or incipient peripheral edema or congestive heart disease has been seen in some patients receiving therapy with Estramustine Capsules. Other conditions which might be influenced by fluid retention, such as epilepsy, migraine, or renal dysfunction, require careful observation.
Estramustine may be poorly metabolized in patients with impaired liver function and should be administered with caution in such patients.
Because Estramustine may influence the metabolism of calcium and phosphorus, it should be used with caution in patients with metabolic bone diseases that are associated with hypercalcemia or in patients with renal insufficiency. Patients with prostate cancer and osteoblastic metastases are at risk for hypocalcemia and should have calcium levels closely monitored.
- Gynecomastia and impotence are known estrogenic effects.
Allergic reactions and angioedema at times involving the airway have been reported.
- Information for the Patient
Because of the possibility of mutagenic effects, patients should be advised to use contraceptive measures.
- Laboratory Tests
Certain endocrine and liver function tests may be affected by estrogen-containing drugs. Estramustine may depress testosterone levels. Abnormalities of hepatic enzymes and of bilirubin have occurred in patients receiving Estramustine. Such tests should be done at appropriate intervals during therapy and repeated after the drug has been withdrawn for two months.
- Food/Drug Interaction
Milk, milk products, and calcium-rich foods or drugs may impair the absorption of Estramustine.
- Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term continuous administration of estrogens in certain animal species increases the frequency of carcinomas of the breast and liver. Compounds structurally similar to Estramustine are carcinogenic in mice. Carcinogenic studies of Estramustine have not been conducted in man. Although testing by the Ames method failed to demonstrate mutagenicity for estramustine phosphate sodium, it is known that both estradiol and nitrogen mustard are mutagenic. For this reason and because some patients who had been impotent while on estrogen therapy have regained potency while taking Estramustine, the patient should be advised to use contraceptive measures.
6. Estramustine 140mg Dosage
The recommended dose of GLOMUSTINE is 14 mg for every kg of body weight each day. The total dose is given in 3 or 4 divided doses during the day.
The capsules should be taken on an empty stomach, at least 1 hour before or 2 hours after meals.
The recommended daily dose is 14 mg per kg of body weight (ie, one 140 mg capsule for each 10 kg or 22 lb of body weight), given in 3 or 4 divided doses. Most patients in studies in the United States have been treated at a dosage range of 10 to 16 mg per kg per day.
Patients should be instructed to take Estramustine Capsules at least 1 hour before or 2 hours after meals. Estramustine should be swallowed with water. Milk, milk products, and calciumrich foods or drugs (such as calcium-containing antacids) must not be taken simultaneously with Estramustine.
Patients should be treated for 30 to 90 days before the physician determines the possible benefits of continued therapy. Therapy should be continued as long as the favorable response lasts. Some patients have been maintained on therapy for more than 3 years at doses ranging from 10 to 16 mg per kg of body weight per day.
Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published.1–8 There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.
7. Uses of Estramustine 140mg
Estramustine Capsules are indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate.
This medication is used to treat some types of cancer. In the body, estramustine breaks down into estrogens (estrone, estradiol) and a type of cancer drug (estromustine). This medication is thought to work by increasing estrogens, which interfere with prostate cancer, and by slowing/stopping the growth of cancer cells.
8. Storage of Estramustine 140mg
Store the U.S. product in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture. Do not store in the bathroom.
Store the Canadian product between 36-77 degrees F (2-25 degrees C) away from light and moisture. Do not store in the bathroom.Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.
Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.