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Buy Ciclopirox

Buy Ciclopirox

Descriptions

Ciclopirox is used to treat infections caused by fungus. It works by killing the fungus or preventing its growth.

Ciclopirox cream, gel, or lotion are applied to the skin to treat:

  • ringworm of the body (tinea corporis);
  • ringworm of the foot (tinea pedis; athlete's foot);
  • ringworm of the groin (tinea cruris; jock itch);
  • “sun fungus” (tinea versicolor; pityriasis versicolor); and
  • certain other fungus infections, such as Candida (Monilia) infections.

Ciclopirox gel or shampoo may also be applied to the scalp to treat seborrheic dermatitis.

Ciclopirox topical solution (nail lacquer) is applied to the nails to treat ringworm of the nails (tinea unguium).

Ciclopirox is available only with your doctor's prescription.

Mechanism of action

In contrast to the azoles and other antimycotic drugs, the mechanism of action of ciclopirox is poorly understood.[3] However, loss of function of certain catalase and peroxidase enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism. In a study conducted to further elucidate ciclopirox's mechanism, several Saccharomyces cerevisiae mutants were screened and tested.

Results from interpretation of the effects of both the drug treatment and mutation suggested that ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport. It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur. Initial results show similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties.

How should this medicine be used?

Ciclopirox comes as a solution to apply to nails and the skin immediately surrounding and under the nails. It is usually applied once a day. To help you remember to use ciclopirox, apply it around the same time every day, usually at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use ciclopirox exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Ciclopirox is used to improve the condition of nails, but may not completely cure nail fungus. It may take 6 months or longer before you notice that your nails are getting better. Continue to use ciclopirox daily as directed. Do not stop using ciclopirox without talking to your doctor.

Ciclopirox topical solution will work best if you trim your nails regularly during your treatment. You should remove all loose nail or nail material using a nail clipper or nail file before you begin treatment and every week during your treatment. Your doctor will show you how to do this. Your doctor will also trim your nails once each month during your treatment.

Ciclopirox Topical Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • unusual or severe itching, redness, burning, dryness, or irritation of treated skin; or
  • discoloration or other changes in the nails.

Common side effects may include:

  • mild burning, itching, or redness.

Conclusions

Studies conducted worldwide demonstrate the efficacy of ciclopirox nail lacquer for the treatment of finger and toe onychomycosis. Both controlled and open-label studies confirm the excellent safety profile of this topical therapy. Thus, the nail lacquer provides a treatment choice with a favorable benefit-to-risk ratio. With its novel mechanism of action and its topical route of administration, ciclopirox nail lacquer offers an innovative approach to the treatment of this often difficult-to-manage disease

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