CA Atra 10 Mg
- Manufacturer : Jenome Biophar Pvt. Ltd
- Equivalent Brands : Vesanoid
- Generic Brands : All-trans Retinoic Acid
Ca atra is a capsule composition of All Trans Retinoic Acid (Tretinoin) which works by promoting the growth of normal, mature cells in the bone marrow and blood. Tretinoin comes in a class of drugs known as retinoids, which are related to vitamin A.
Retinoids are drugs that are relatives of vitamin A. Retinoids control normal cell growth, cell differentiation (the normal process of making cells different from each other), and cell death during embryonic development and in certain tissues later in life. Retinoids effects on the cells are controlled by receptors on the nucleus of each cell (nuclear receptors).
There are two major classes of retinoid nuclear receptors: retinoic acid receptors (RAR) and retinoid-X-receptors (RXR). There are also subtypes within each class. Each of these types of receptors has different functions in different tissues. The different retinoid drugs work by binding to different receptors; which, in turn, affect cell growth and differentiation.
Retinoids are relatively new types of anti-cancer drugs. They have been used alone or in combination to treat a variety of cancers such as skin cancers, cutaneous T-cell lymphoma, acute promyelocytic leukemia, lung cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, and head and neck cancers. Retinoids have also been used experimentally in an attempt to prevent certain types of cancer. There is ongoing research to determine their role in both cancer treatment and prevention.
Retinoids have been associated with side effects such as skin problems (dryness, peeling, itching, sun sensitivity), reversible elevation in liver enzymes, temporary abnormal lipid levels, low thyroid levels (hypothyroidism), and headaches. Taking supplemental doses of vitamin A may increase the side effects. Vitamin supplementation should be discussed with your physician.
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.
Drink 2 to 3 quarts of fluid every 24 hours, unless you were told to restrict your fluid intake, and maintain good nutrition. This will decrease your chances of being constipated, and prevent dehydration.
When you start taking ATRA, you may become dizzy, confused, anxious, or extremely tired. Do not attempt to drive or operate heavy machinery, unless you know how you will respond to ATRA.
Avoid wearing contact lenses if you have dry or irritated eyes.
Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1/2 to 1 teaspoon of baking soda and/or 1/2 to 1 teaspoon of salt mixed with 8 ounces of water.
Keep your bowels moving. Your health care provider may prescribe a stool softener to help prevent constipation that may be caused by ATRA.
In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
Do not share your medicines with anyone. Keep out of reach of children.
If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.
Before starting ATRA treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Do not receive any kind of immunization or vaccination without your doctor's approval while taking ATRA.
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (ATRA may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).
Because of the extremely high risk that a deformed infant can result if pregnancy occurs while taking ATRA in any amount even for short periods of time, for both men and women: Do not conceive a child (get pregnant) while taking ATRA. Two methods of effective contraception are recommended for women of childbearing potential, unless absolute abstinence is the chosen method. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking ATRA.
Ca atra retinoic acid is used to treat a type of leukemia (cancer of the white blood cells) known as acute promyelocytic leukemia (APL). It kills certain types of cancer cells by interfering with their growth and reproduction.
ATRA is used to treat acute promyelocytic leukemia (APL, APML).
Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.
Store away from heat, moisture, and light. Do not store in the bathroom. Keep CA ATRA-10 out of the reach of children and away from pets.