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Buy Azacitidine

Buy Azacitidine

What Is Azacitidine?

Azacitidine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Azacitidine is used to treat certain types of bone marrow cancers and blood cell disorders.

Azacitidine may also be used for purposes not listed in this medication guide.

You should not receive this medicine if you have liver cancer.

You should not receive this medicine if you are allergic to azacitidine or mannitol, or if you have:

  • liver cancer.

To make sure azacitidine is safe for you, tell your doctor if you have:

  • kidney disease; or
  • history of liver disease.

Do not use azacitidine if you are pregnant. It could harm the unborn baby.

Side Effects:

  • Important things to remember about the side effects of azacitidine:
  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • Side effects are almost always reversible and will go away after treatment is complete.
  • There are many options to help minimize or prevent side effects.
  • There is no relationship between the presence or severity of side effects and the effectiveness of the medication

The following side effects are common (occurring in greater than 30%) for patients taking azacitidine:

  • Nausea
  • Low red blood cell count (Anemia).
  • Low platelet count.  (This can put you at increased risk for bleeding.)
  • Vomiting
  • Fever
  • Low white blood cell count. (This can put you at increased risk for infection.)

Precautions

Before starting azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).  

Do not receive any kind of immunization or vaccination without your doctor's approval while taking azacitidine.

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment.  Pregnancy category D (azacitidine may be hazardous to the fetus.  Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.)

For both men and women: Do not conceive a child (get pregnant) while taking azacitidine. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

Do not breast feed while taking this medication.

How Azacitidine Works

Azacitidine is a member of a new class of drugs known as DNA "demethylating" agents.  Methylation of DNA is a major mechanism that regulates gene expression in cells.  When there is an increase in DNA methylation this can result in the blockage of the activity of "suppressor genes" that regulate cell division and growth.  When suppressor genes are blocked, cell division becomes unregulated, allowing or promoting cancer.

Azacitidine's anticancer effects are believed to be twofold.   One way that it works is by demethylation or interfering with the methylation of DNA.  By this process of demethylation, normal function to the tumor suppressor genes is restored, thus restoring control over cell growth.

Azacitidine also belongs to the category of chemotherapy called antimetabolites.  Antimetabolites are very similar to normal substances within the cell.  When the cells incorporate these substances into the cellular metabolism, they interact with a number of targets within the cell to produce a direct cytotoxic effect that causes death of rapidly dividing cancer cells.

How should this medicine be used?

Azacitidine comes as a powder to be mixed with water and injected subcutaneously (under the skin) or intravenously (into a vein) by a doctor or nurse in a medical office or hospital outpatient department. It is usually injected once a day for 7 days. This treatment may be repeated every 4 weeks for as long as your doctor recommends. Treatment should usually be given for at least four cycles.

Your doctor may increase your dose of azacitidine after two cycles if your condition has not improved and if you have not experienced serious side effects of the medication. Your doctor may also need to delay your treatment or reduce your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with azacitadine.

Your doctor will give you medication to prevent nausea and vomiting before you receive each dose of azacitadine.

How it works

Azacitidine is a type of drug called a hypomethylating agent. It works by switching off a protein called DNA methyltransferase.

This switches on genes that stop the cancer cells growing and dividing. This reduces the number of abnormal blood cells and helps to control cell growth.

How is Azacitidine administered?

You have azacitidine as an injection just under your skin (subcutaneously) given by a doctor or nurse. This can be in your upper arm, leg, buttock or stomach. You usually have it as an outpatient but there have been successful experiences with home administration.

You will have azacitidine as a course of several cycles of treatment. You can a treatment each day for a week and then 3 weeks with no treatment. This makes up a treatment cycle. You normally have at least 6 cycles and the treatment continues for as long as it is working.

You can also have it every day, for 5 days. Then have 2 days off and have azacitidine again for 2 days at the start of the next week.

 

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