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Buy Ambrisentan

Buy Ambrisentan

What Is Ambrisentan?

Ambrisentan prevents thickening of the blood vessels, especially those in the lungs and heart. Ambrisentan also lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

Ambrisentan is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse. Ambrisentan is sometimes used with a medicine called tadalafil (Adcirca).

Ambrisentan is available only from a certified pharmacy under a special program called LEAP (Letairis Education and Access Program). You must be registered in the program and sign agreements to use birth control and undergo pregnancy and blood testing.

How does ambrisentan work?

Ambrisentan works by blocking endothelin, a substance made by the body. Endothelin causes blood vessels to narrow (constrict). It also causes abnormal growth of the muscle in the walls of the blood vessels in the lungs. This narrowing increases the pressure required to push the blood through the lungs to get oxygen. By blocking the action of endothelin, causing vessels to relax, ambrisentan decreases the pulmonary blood pressure to the heart and improves its function. This generally results in the ability to be more active. Research studies have verified this improvement.

How do patients obtain ambrisentan?

Ambrisentan is a limited distribution medication, which means it cannot be purchased at a local pharmacy. It must be prescribed by a physician through the Letairis® Education and Access Program (LEAP) and insurance approval must be obtained prior to starting therapy. LEAP will forward the request to a specialty pharmacy. Ambrisentan is then sent to patients monthly by any of the following specialty pharmacies: Accredo Health Group Inc., Aetna Specialty Pharmacy, CVS Caremark, Cigna Tel-Drug, CuraScript, Kaiser Permanente Specialty Pharmacy, Walgreens Specialty Pharmacy (Medmark), and WellCare. Ambrisentan can only be obtained through the Letairis® Education and Access Program (LEAP).

What are the frequent side effects of ambrisentan?

Ambrisentan is generally well tolerated. The most frequent side effects are:

  • Swelling of legs or abdomen (fluid retention)
  • Nasal stuffiness or congestion
  • Inflammation of the sinuses
  • Flushing of the skin
  • Rapid or skipped heart beats
  • Abdominal pain
  • Constipation
  • Elevated liver function tests


Before taking ambrisentan, tell your doctor or pharmacist if you are allergic to it; or to other endothelin receptor blockers (e.g., bosentan); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, certain lung conditions (pulmonary fibrosis), anemia.

Older adults may be at greater risk for swelling ankles/feet while using this drug.

This medication must not be used during pregnancy. It may harm an unborn baby. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away. Women who may become pregnant must have a negative pregnancy test before starting this medication, once a month while taking it, and for 1 month after stopping the medication. Consult your doctor for more details and to discuss reliable forms of birth control.