When Should You Avoid Generic Viagra (Part 2)

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When Should You Avoid Generic Viagra 1

We discussed few of the generic Viagra (a drug for treating Erectile Dysfunction) contraindications in the first part of the blog series.

In the given piece, we shall discuss few more contraindicated drugs which have adverse reactions with Sildenafil— the primary medical content in generic Viagra.

But before we start this part, let me give a brief overview of contraindications.

Contraindication

 It’s a medical condition when a drug shouldn’t be given to a patient, or the volume of the drug should be prescribed in a controlled environment.

The simultaneous use of multiple drugs may result in the inevitable and unwanted results leaving body unprotected against dangerous repercussions.

The previously discussed Sildenafil Contraindication

 Nitrates, Alpha-blockers, Riociguat, Protease Inhibitors.

Avoid Generic Viagra (part 2)

When you intake Anti-fungal

Antifungal substances help to overcome fungal infection by releasing ergosterol. They interfere with the cell membranes by drilling a hole in it. As cell membranes are essential for fungus growth, the pores in the membrane lead to the cleanup of fungal infection.

Medicines: ketoconazole (Nizoral) and itraconazole (Sporanox)

Threat: Usually, Sildenafil has Some of the studies demonstrate that the use of Antifungal medicine could inhibit CYP3A4 enzyme— an enzyme responsible for the metabolism of the drug. If Sildenafil is co-administered with antifungal, the rate of metabolism is reduced. As a result, the effect of the medicine stays longer than the anticipated. The long-time impact could lead to dangerous issues like penile rupture, penile hemorrhage, or permanent penile damage [1].

When you intake Antibiotics

 Antibiotic medicines protect the body from the bacterial infection by attacking the cell wall and cell content of the bacteria and prevent them from multiplication.

Medicines: Clarithromycin (Biaxin), Telithromycin (Ketek), Erythromycin

Threat: CYP3A4 enzyme metabolizes Sildenafil, i.e., the enzyme oxidizes the drug and leads to the first pass metabolism of the drug. Usually, the bioavailability of Sildenafil is 41%, i.e., the rate of absorption. The given enzyme is inhibited when Sildenafil-rich generic Viagra gets induced with the antibiotics. It results in lesser first-pass metabolism and increased bioavailability. The surged bioavailability enhances the activity of Sildenafil exposing you to the threats of penile damage [2].

When you intake PDE5-inhibitors

By chemical nature, Sildenafil is itself a Phosphodiesterase-5 (PDE5) Inhibitor. PDE5 inhibitors are given for treating high blood pressure conditions like Benign Hyperplasia, pulmonary arterial hypertension, etc. They are also used for treating Erectile Dysfunction.

The PDE5 inhibitors relax the muscle wall and create room for blood vessel widening.

As arteries get widened, there is an inrush in the blood flow and decrease in the blood pressure.

Medicines: Tadalafil, Udenafil, Avanafil, Vardenafil, etc.

Threat: Adding Sildenafil with Tadalafil lead to dual therapy. It means that your body is receiving more dilating substance than it should get. Sequential administration could cause drug overdose followed by corollary diseases like vision issues, hearing problems, etc.

When you intake Sildenafil

Well, this sounds bizarre, but there are chances that you may induce Sildenafil over the existing Sildenafil dose for treating your ED and pulmonary hypertension. As we know that Sildenafil leeways the growth of cGMP neurotransmitter level, the repetitive admission of Sildenafil is very dangerous as it leads to double therapy causing more cGMP production.

Medicine: Revatio, Malegra 50mg, Fildena 100mg

Threat: The initial Sildenafil dose works best at 25 mg. However, double admission induces more Sildenafil content than the required treatment. The drug abuse of Sildenafil opens the gate for various side-effects like eyesight issues, audibility problems, permanent penile erection, etc. [3]

Conclusion

As you have seen that the cross-interactivity and biochemical reaction between the multiple-chemicals could lead to threatening disorders, it’s highly recommended to stay honest with your doctor while discussing your medical history, background, and the current medical condition.

If you are longing for answers to your medical inquiries, you can contact us— MedyPharma— your medical store.

Tell us about your medical history, and we will come up with the precise medicine, dosage, etc.