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Beclomethasone+ Formoterol Fumarate

Beclomethasone+ Formoterol Fumarate

Abstract

The GOLD 2017 strategy document recommends that the pharmacological management of COPD patients be based on the risk of future exacerbations and the severity of symptoms. A threshold of two moderate exacerbations or one hospitalization is used to define high-risk patients. The FORWARD study was a randomized, double-blind, parallel-group trial that compared 48 weeks' treatment with extrafine beclomethasone dipropionate plus formoterol fumarate (BDP-FF) versus FF in severe COPD patients with a history of one or more exacerbations in the previous year. The new GOLD 2017 recommendations mean that many patients in the FORWARD study are now reclassified as GOLD B. We conducted a post hoc analysis of the FORWARD study, in order to investigate the effects of extrafine BDP/FF in patients with one exacerbation in the previous year, focusing on those categorized as group B using the GOLD 2017 definition. The analysis showed a 35% reduction in exacerbation rate with an inhaled corticosteroid (ICS) + long-acting β-agonist (LABA) versus LABA. We propose that ICS-LABA treatment is a therapeutic option for COPD patients with one exacerbation in the previous year.

Uses

Formoterol Fumarate / Beclomethasone Dipropionate is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

  • Asthma
  • Exercise-induced bronchospasm
  • Chronic obstructive pulmonary disease
  • Allergic rhinitis
  • Formoterol Fumarate / Beclomethasone Dipropionate may also be used for purposes not listed here.

Precautions

Before using Formoterol Fumarate / Beclomethasone Dipropionate, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

  • do not exceed the recommended dosage
  • patients should be carefully monitored in case of change in vision or with a history of increased intraocular pressure, glaucoma

Interactions with Formoterol Fumarate / Beclomethasone Dipropionate

If you use other drugs or over the counter products at the same time, the effects of Formoterol Fumarate / Beclomethasone Dipropionate may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Formoterol Fumarate / Beclomethasone Dipropionate may interact with the following drugs and products:

  • Adrenergic drugs
  • Beta-blockers
  • Diuretics
  • Halogenated hydrocarbons
  • Macrolides
  • Monoamine oxidase inhibitors
  • Tricyclic antidepressants
  • Xanthine derivatives
  • No drug interaction reported

Storage of Formoterol Fumarate / Beclomethasone Dipropionate

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Formoterol Fumarate / Beclomethasone Dipropionate.

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