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Azithromycin Vs Amoxicillin

azithromycin vs amoxicillin


Azithromycin is a macrolide antibiotic commonly prescribed for outpatient treatment of respiratory infections, urinary tract infections, and sexually transmitted diseases.Macrolide antibiotics, primarily erythromycin and clarithromycin, are known to increase cardiac arrhythmogenic risks, including QT interval prolongation, torsades de pointes, and polymorphic ventricular tachycardia. Between 2001 and 2007, case reports described arrhythmias among persons receiving azithromycin. In 2012, Ray et al reported increased risks of cardiovascular death and all-cause mortality among adult, predominantly female, Medicaid patients in Tennessee who received azithromycin compared with amoxicillin, particularly among those with a high baseline risk for cardiovascular disease. Subsequently, the Food and Drug Administration (FDA)and pharmaceutical manufacturer issued public safety notifications warning of QT prolongation risks with azithromycin. 

Azithromycin vs Amoxicillin

Both Azithromycin and Amoxicillin are antibiotics that are used to treat a horde of bacterial infections. However, they are effective on different bacteria and on different parts of the body. For this reason, it is very important that you should be aware of the differences. Here is an estimate of the two, based on their indications, dosage, side effects and other factors.


Your doctor may prescribe amoxicillin in case of acute otitis, respiratory tract disease or urinary tract infections.

It can also be prescribed as a prophylaxis before surgery or a medical procedure.

Azithromycin is prescribed for upper respiratory tract diseases, skin and soft tissue infections and genitourinary tract infections by susceptible bacteria.


Amoxicillin is contraindicated in cases where the patient has a reaction to penicillin. The most dangerous part of it is that the patient may go into an anaphylactic shock because of penicillin treatment.
Patients with impaired liver functions are usually advised against azithromycin.


1.Amoxicillin may be prescribed in doses of 500 mg every 8 hours for people weighing over 20kgs and having severe infections. They may also be prescribed as doses of 250 mg every 8 hours for less severe infections.

2.Azithromycin should be taken as a single dose every day for a single day or a period of three days or more. The main difference between the two is that azithromycin should be taken at least an hour before food or two hours after a meal.

side effects

1. The side effects of amoxicillin include diarrhea, vomiting, gastritis, a black and hairy tongue or pseudomembranous colitis. Patients may also have bloody diarrhea and abdominal pain. Rarely, it can also lead to acute nephritis, anemia and other associated blood disorders.

2. The side effects of azithromycin are mainly gastrointestinal in nature. Patients may also experience urticaria, vasculitis or cardiac arrhythmia.


Azithromycin and amoxicillin present similar efficacy and tolerability in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

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