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Azithromycin In Pregnancy

azithromycin in pregnancy

About azithromycin

Azithromycin is an antibiotic.

It's widely used to treat chest infections such as pneumonia, infections of the nose and throat such as sinusitis, skin infections, Lyme disease, and some sexually transmitted infections.

Azithromycin is used in children, often to treat ear infections or chest infections.

It can also be used long term to prevent chest infections in people who keep getting them.

The medicine is available on prescription as capsules, tablets and a liquid that you drink. It can also be given by injection, but this is usually only done in hospital.

Dosage

The injectable form of azithromycin is given directly in the vein (IV) by a healthcare professional.

Take all other forms of azithromycin exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

Your doctor will determine the best dose for you or your child based on the type of infection and the patient's age.

Azithromycin Pregnancy Warnings

Animal models given moderately maternally toxic doses have failed to reveal evidence of feto- or teratogenicity. There are no controlled data in human pregnancy.

Au Tga pregnancy category B1: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage.

Us Fda pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Use is not recommended unless clearly needed.

Side Effects of Azithromycin

Serious side effects have been reported with azithromycin. See “Drug Precautions” section.

Common side effects of azithromycin in the tablet, oral solution, and injection forms include:

  • nausea
  • vomiting
  • diarrhea
  • stomach pain
  • heartburn
  • headache

Common side effects of azithromycin in the eye drop form include:

  • eye burning, stinging and irritation
  • dry eye
  • discharge coming from your eye
  • changes to the surface of your eye
  • blurred vision

This is not a complete list of azithromycin side effects. Ask your doctor or pharmacist for more information.

Azithromycin Precautions

Azithromycin should not be used for extended periods of time. Prolonged use can lead to the growth of dangerous organisms that are resistant to azithromycin. Take azithromycin for the duration prescribed by your doctor.

Clostridium difficile associated diarrhea: Azithromycin and other antibiotics can kill the “good” bacteria in the colon leading to a growth of C. difficile bacteria. C. difficile is “bad” bacteria that can cause diarrhea.

Heart rhythm changes: Azithromycin can cause abnormal changes in the electrical activity of the heart that may lead to a potentially life-threatening irregular heart rhythm.

Conclusion

Results suggest that gestational exposure to azithromycin is not associated with an increase in the rate of major malformations above the baseline of 1–3%. Our data adds to previous research showing that macrolide antibiotics, as a group, are generally safe in pregnancy and provides an evidence-based option for health professionals caring for populations with chlamydia.

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