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Apixaban Vs Warfarin

Apixaban Vs Warfarin

apixaban vs warfarin– Which is Best?

When deciding what type of blood thinner is best, the question of apixaban vs warfarin often arises.  Blood thinners, also called anticoagulants, are a class of medications that “thin” or prolong the time it takes for your blood to form a blood clot. Simply put, blood thinners stop blood clots. The usefulness of blood thinners comes from their power to prevent blood clots and reduce or eliminate blood clots that have already formed in your veins, arteries, or organs. This ability makes blood thinners an important class of medications for the treatment, prevention, or management of a variety of medical conditions including, but not limited to:

  • Stroke in atrial fibrillation (AFib)
  • Deep vein thrombosis (DVT)
  • Pulmonary thromboembolism (PTE)
  • Acute myocardial infarction (AMI or “heart attack”)
  • Heart valve surgeries and certain heart valves
  • Certain congenital heart defects
  • Genetic or acquired hypercoagulable states

How Do New Blood Thinners Compare to apixaban vs warfarin ?

Not too long ago, if your doctor said you needed a blood thinner to prevent a stroke, you didn't have to think too hard about it. Warfarin (Coumadin) was the only way to go. But not anymore. With four other medications to pick from, you'll have to do a little homework to figure out what's best for you.

"It's not a one-size-fits-all choice," says Bruce Lindsay, MD, from Cleveland Clinic. A lot depends on your overall health and your lifestyle.

 Have Atrial Fibrillation: Which Blood Thinner Should I Take?

Atrial fibrillation is an abnormal heart rhythm that results in reduced active squeezing of the upper heart chambers, which causes blood flow to slow and enables blood clots to form. These clots can then be injected to the body organs, and if they reach the brain, a stroke can occur. Because of this, stroke prevention includes taking blood thinning medications.

What Are My Options?

  • Apixaban (Eliquis)
  • Dabigatran (Pradaxa)
  • Edoxaban (Savaysa)
  • Rivaroxaban (Xarelto)

Which One Works Best?

Studies show the latest drugs work as well as apixaban vs warfarin . But trying to figure out how the new medicines compare to each other is a bit trickier. There isn’t any research that compares them head to head.

Drug/Procedures Used:

Patients were randomized to receive either apixaban vs warfarindaily (2.5 mg twice daily in selected patients) or dose-adjusted warfarin (titrated to a target international normalized ratio [INR] range of 2.0-3.0). The 2.5 mg dose was used in patients with at least two of the following criteria: age ≥80 years, body weight ≤60 kg, and/or serum creatinine ≥1.5 mg/dl (approximately 4.8% of the total population).


apixaban vs warfarin is a novel anti-Xa oral anticoagulant, with a mechanism of action similar to other agents such as rivaroxaban. Rivaroxaban demonstrated noninferiority compared with warfarin in the ROCKET AF trial in reducing systemic embolism in patients with AF. In the AVERROES trial, apixaban demonstrated superiority compared with aspirin in reducing the risk of strokes in patients with AF. The current trial extends those findings, and demonstrates superiority for stroke/systemic embolism with apixaban compared with warfarin, with a better bleeding profile. In addition, it is a twice-daily oral medication that does not require routine INR or other blood level monitoring, thereby being more convenient to use compared with warfarin.

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