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Apixaban Dosing

Apixaban Dosing

What is apixaban?

Apixaban (brand name Eliquis) is an anticoagulant medicine. “Anti”means against, and “coagulant” refers to blood clotting. An anticoagulant helps keep clots from forming in your blood.Apixaban is sometimes called a “blood-thinner,” but it does not thin yourblood. It works by blocking the part of your blood that normally forms clots.

Why am I taking apixaban?

Your doctor has prescribed apixaban to keep harmful blood clots fromforming. Blood clots can occur in people who have a heart conditioncalled atrial fibrillation.In atrial fibrillation, part of the heart does not beat the way it should.This can make blood clots form within the heart. Parts of these clots canbreak off and travel to the brain.A blood clot in the brain can cause astroke. Apixaban lowers the chance ofclots forming and causing a stroke.

How does it work?

Many things must happen inside the body for a blood clot to form. Parts of the blood called clotting factors are involved in each step of this process.

Apixaban blocks the clotting factor called factor Xa. This keeps clotsfrom forming.

How long does it take for apixaban to work?

Apixaban begins to reduce blood clotting within a few hours after takingthe first dose. If you stop taking apixaban, its effects on clotting begin towear off within 24 hours for most people.

EFFECTIVENESS

apixaban dosing was compared with aspirin therapy in 5,600 patients who had chronic atrial fibrillation and at least one additional risk factor for stroke, but for whom warfarin therapy was unsuitable. The likelihood of stroke was lower with apixaban dosing than with aspirin (NNT = 50 per 1.1 years; 95% confidence interval, 44 to 84).1 Systemic embolism risk was also lower with apixaban. In addition, the annual risk of death from any cause was not significantly different in patients taking apixaban vs. aspirin.

Apixaban is similarly effective to warfarin for stroke prevention. In a study of 18,201 patients with atrial fibrillation or flutter and at least one additional risk factor for major stroke (i.e., based on the CHADS2 stroke risk prediction tool [congestive heart failure, hypertension, age 75 years or older, diabetes mellitus, and stroke or transient ischemic attack]).

Eliquis Side Effects

apixaban dosing  is an anticoagulant (blood thinner) that reduces blood clotting and reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. The most common side effects of Eliquis are related to bleeding. Other side effects of Eliquis include:

  • skin rash,
  • allergic reactions,
  • fainting, nausea, and
  • anemia.

How much apixaban should I take?

Apixaban comes in 5 mg and 2.5 mg tablets. The dose will depend on your age, weight, and how well your kidneys are working, as well as other medicines you take. Your doctor will decide which dose is right for you. Apixaban is taken two times a day.

Most people take one of these doses:

• 5 mg, two times a day

Or

• 2.5 mg, two times a day

Miss dose

If a dose of (apixaban) is not taken at the scheduled time, the dose should be taken as soon as possible on the same day and twice-daily administration should be resumed. The dose should not be doubled to make up for a missed dose.1

Drugs affecting hemostasis

  • Aspirin and other antiplatelet agents
  • Other anticoagulants
  • Heparin
  • Thrombolytic agents
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), when used chronically
  • Fibrinolytics

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