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Apixaban Classification

Apixaban Classification


apixaban classification is an oral, direct, and highly selective factor Xa (FXa) inhibitor (of both free and prothrombinase-bound FXa independently of antithrombin III) for the prevention and treatment of thromboembolic diseases. It is marketed under the name Eliquis. FDA approved on December 28, 2012.


apixaban classification is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming, which can travel to other parts of your body (such as the lungs or legs) or increase your risk for stroke. In the United States, apixaban is also approved to treat certain types of blood clots (deep vein thrombosis-DVT, pulmonary embolus-PE) and to prevent them from forming again.

Apixaban is an anticoagulant that works by blocking certain clotting proteins in your blood.

How to use Apixaban Tablet

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking apixaban and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice daily (every 12 hours). If you cannot swallow the tablet whole, you may crush the tablet and mix with water, apple juice, or applesauce and take it right away.


Premature discontinuation increases risk of thrombotic events; if discontinued for reason other than bleeding or therapy completion, consider alternative anticoagulant. Risk of spinal/epidural hematoma in anticoagulated patients receiving neuraxial anesthesia or undergoing spinal/epidural puncture (see full labeling); monitor for signs/symptoms of neurological impairment. Increased risk of bleeding; evaluate any signs/symptoms of blood loss; discontinue if active pathological hemorrhage occurs. Patients with prosthetic heart valves, as initial treatment of PE in hemodynamically unstable patients or who require thrombolysis or pulmonary embolectomy: not recommended. Moderate hepatic impairment. Severe hepatic impairment: not recommended. Labor & delivery. Pregnancy (Cat.B).

Side effects

Apixaban can increase the risk of bleeding which may be serious and potentially fatal. Concurrent use with drugs that affect hemostasis can further increase this risk. This includes drugs such as other anticoagulants, heparin, aspirin, antiplatelet drugs, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs)[5]

One concern with the use of apixaban and the other newer anticoagulants is the absence of well-established protocol for reversal of their activity (no antidote is available). This is an important disadvantage relative to warfarin when bleeding complications occur, or when people taking the drugs require emergency surgery.

What is the dosage for apixaban?

The usual dose in nonvalvular atrial fibrillation is 5 mg by mouth twice daily. For individuals 80 years or older, weighing less than or equal to 60 kg, or with reduced kidney function, the usual dose is 2.5 mg twice daily.

The recommended dose for treating DVT or pulmonary embolism is 10 mg twice daily for the first 7 days and then 5 mg twice daily. After six months of treatment, the dose may be reduced to 2.5 mg daily for prevention of DVT or pulmonary embolism.

Drug Class

Apixaban is best broadly described as a blood thinner. This is a misnomer, however. This is because blood thinners don't actually thin out or dilute your blood. Blood thinners make your blood less likely to clot, that's all.

Blood thinners come in two major categories. They can either be antiplatelet drugs, like the famous aspirin can be, or they can be anticoagulants, like the famous warfarin (Coumadin). Don't get these two general types of blood thinners confused with thrombolytics, however. Thrombolytics are better known as 'clot busters'. In other words, they dissolve clots after they have formed. Anticoagulants and antiplatelet medications try to prevent clots from forming in the first place.

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