Anti Migraine Drugs
Generic: SumatriptanGeneric: SumatriptanGeneric: SumatriptanGeneric: RizatriptanGeneric: RizatriptanGeneric: Naproxen
Migraines are severe, recurring, and painful headaches. They can be preceded or accompanied by sensory warning signs and other symptoms.
The extreme pain that migraines cause can last for hours or even days.
According to the American Migraine Association, they affect 36 million Americans, or approximately 12 percent of the population.
Migraines can follow an aura of sensory disturbances followed by a severe headache that often appears on one side of the head. They tend to affect people aged 15 to 55 years.
If you have migraines or a family history of migraines, a doctor trained in treating headaches (neurologist) will likely diagnose migraines based on your medical history, symptoms, and a physical and neurological examination.
Your doctor may also recommend more tests to rule out other possible causes for your pain if your condition is unusual, complex or suddenly becomes severe.
- Blood tests. Your doctor may order these to test for blood vessel problems, infections in your spinal cord or brain, and toxins in your system.
- Magnetic resonance imaging (MRI). An MRI uses a powerful magnetic field and radio waves to produce detailed images of the brain and blood vessels.
- MRI scans help doctors diagnose tumors, strokes, bleeding in the brain, infections, and other brain and nervous system (neurological) conditions.
- Computerized tomography (CT) scan. A CT scan uses a series of X-rays to create detailed cross-sectional images of the brain. This helps doctors diagnose tumors, infections, brain damage, bleeding in the brain and other possible medical problems that may be causing headaches.
- Spinal tap (lumbar puncture). Your doctor may recommend a spinal tap (lumbar puncture) if he or she suspects infections, bleeding in the brain or another underlying condition.
In this procedure, a thin needle is inserted between two vertebrae in the lower back to remove a sample of cerebrospinal fluid for analysis in a lab.
Migraine treatments can help stop symptoms and prevent future attacks.
Many medications have been designed to treat migraines. Some drugs often used to treat other conditions also may help relieve or prevent migraines. Medications used to combat migraines fall into two broad categories:
- Pain-relieving medications. Also known as acute or abortive treatment, these types of drugs are taken during migraine attacks and are designed to stop symptoms.
- Preventive medications. These types of drugs are taken regularly, often on a daily basis, to reduce the severity or frequency of migraines.
Your treatment strategy depends on the frequency and severity of your headaches, the degree of disability your headaches cause, and your other medical conditions.
Some medications aren't recommended if you're pregnant or breast-feeding. Some medications aren't given to children. Your doctor can help find the right medication for you.
Take pain-relieving drugs as soon as you experience signs or symptoms of a migraine for the best results. It may help if you rest or sleep in a dark room after taking them. Medications include:
Pain relievers. Aspirin or ibuprofen (Advil, Motrin IB, others) may help relieve mild migraines.
Acetaminophen (Tylenol, others), also may help relieve mild migraines in some people.
Drugs marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease moderate migraine pain. They aren't effective alone for severe migraines.
If taken too often or for long periods of time, these medications can lead to ulcers, gastrointestinal bleeding and medication-overuse headaches.
The prescription pain reliever indomethacin may help thwart a migraine and is available in suppository form, which may be helpful if you're nauseated.
Triptans. These medications are often used in treating migraines. Triptans make blood vessels constrict and block pain pathways in the brain.
Triptans effectively relieve the pain and other symptoms that are associated with migraines. They are available in pill, nasal spray and injection form.
Side effects of triptans include reactions at the injection site, nausea, dizziness, drowsiness and muscle weakness. They aren't recommended for people at risk of strokes and heart attacks.
A single-tablet combination of sumatriptan and naproxen sodium (Treximet) has proved to be more effective in relieving migraine symptoms than either medication on its own.
Ergots. Ergotamine and caffeine combination drugs (Migergot, Cafergot) are less effective than triptans. Ergots seem most effective in those whose pain lasts for more than 48 hours. Ergots are most effective when taken soon after migraine symptoms start.
Ergotamine may worsen nausea and vomiting related to your migraines, and it may also lead to medication-overuse headaches.
Dihydroergotamine (D.H.E. 45, Migranal) is an ergot derivative that is more effective and has fewer side effects than ergotamine. It's also less likely to lead to medication-overuse headaches. It's available as a nasal spray and in injection form.
Anti-nausea medications. Medication for nausea is usually combined with other medications. Frequently prescribed medications are chlorpromazine, metoclopramide (Reglan) or prochlorperazine (Compro).
Opioid medications. Opioid medications containing narcotics, particularly codeine, are sometimes used to treat migraine pain for people who can't take triptans or ergots. Narcotics are habit-forming and are usually used only if no other treatments provide relief.
Glucocorticoids (prednisone, dexamethasone). A glucocorticoid may be used with other medications to improve pain relief. Glucocorticoids shouldn't be used frequently to avoid side effects.
You may be a candidate for preventive therapy if:
- You have four or more debilitating attacks a month
- Attacks last more than 12 hours
- Pain-relieving medications aren't helping
Your migraine signs and symptoms include a prolonged aura or numbness and weakness
Preventive medications can reduce the frequency, severity and length of migraines and may increase the effectiveness of symptom-relieving medicines used during migraine attacks. It may take several weeks to see improvements in your symptoms.
Your doctor may recommend daily preventive medications, or only when a predictable trigger, such as menstruation, is approaching.
Preventive medications don't always stop headaches completely, and some drugs cause serious side effects. If you have had good results from preventive medicine and your migraines are well-controlled, your doctor may recommend tapering off the medication to see if your migraines return without it.
Preventive migraine medications include:
Cardiovascular drugs. Beta blockers, which are commonly used to treat high blood pressure and coronary artery disease, may reduce the frequency and severity of migraines.
The beta blockers propranolol (Inderal LA, Innopran XL, others), metoprolol tartrate (Lopressor) and timolol (Betimol) have proved effective for preventing migraines. Other beta blockers are sometimes used for the treatment of migraine. You may not notice improvement in symptoms for several weeks after taking these medications.
If you are older than age 60, use tobacco, or have certain heart or blood vessel conditions, your doctor may recommend a different type of medication.
Another class of cardiovascular medications (calcium channel blockers) used to treat high blood pressure also may be helpful in preventing migraines and relieving symptoms. Verapamil (Calan, Verelan, others) is a calcium channel blocker that may help prevent migraines with aura.
In addition, the angiotensin-converting enzyme inhibitor lisinopril (Zestril) may be useful in reducing the length and severity of migraines.
Antidepressants. Tricyclic antidepressants may be effective in preventing migraines, even in people without depression.
Tricyclic antidepressants may reduce the frequency of migraines by affecting the level of serotonin and other brain chemicals. Amitriptyline is the only tricyclic antidepressant proved to effectively prevent migraines. Other tricyclic antidepressants are sometimes used because they may have fewer side effects than amitriptyline.
These medications can cause sleepiness, dry mouth, constipation, weight gain and other side effects.
SSRIs haven't been proved to be effective for migraine prevention. These drugs may even worsen or trigger headaches.
However, research suggests that one serotonin and norepinephrine reuptake inhibitor, venlafaxine (Effexor XR), may be helpful in preventing migraines.
Anti-seizure drugs. Some anti-seizure drugs, such as valproate (Depacon) and topiramate (Topamax), seem to reduce the frequency of migraines.
In high doses, however, these anti-seizure drugs may cause side effects. Valproate may cause nausea, tremor, weight gain, hair loss and dizziness. Don't use valproate if you are pregnant or may become pregnant.
Topiramate may cause diarrhea, nausea, weight loss, memory difficulties and concentration problems.
Pain relievers. Taking nonsteroidal anti-inflammatory drugs, especially naproxen (Naprosyn), may help prevent migraines and reduce symptoms.
OnabotulinumtoxinA (Botox). OnabotulinumtoxinA, which is administered by your doctor during an office visit, has been shown to be helpful in treating chronic migraines in adults.
During this procedure, onabotulinumtoxinA is injected into the muscles of the forehead and neck. When this is effective, the treatment usually needs to be repeated every 12 weeks.
Erenumab-aooe (Aimovig). This once-monthly, self-injected drug is the first in a new class of drugs. Erenumab-aooe inhibits the activity of a molecule known to play a role in migraines.Anti Migraine Drugs
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