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Anastrozole Vs Letrozole

Anastrozole vs Letrozole

About Anastrozole vs. Letrozole

  • Anastrozole and letrozole are both aromatase inhibitors, anti-cancer medications used for treating postmenopausal women with breast cancer.
  • The brand name for anastrozole is Arimidex and the brand name for letrozole is Femara. Both drugs are available in generic form.
  • Side effects of anastrozole and letrozole that are similar include nausea, vomiting, and headache.
  • Side effects of anastrozole that are different from letrozole include hot flashes, pain, arthritis, increased blood pressure, depression, bone pain, weakened bones, sleeplessness, and rash.
  • Side effects of letrozole that are different from anastrozole include fatigue, muscle aches, diarrhea, constipation, and chest pain.
  • Both anastrozole and letrozole should not be used with tamoxifen because tamoxifen can reduce anastrozole and letrozole levels in the body and decrease their therapeutic effects.

What are the side effects of anastrozole and letrozole?

  • hot flashes,
  • pain,
  • arthritis,
  • headache,
  • increased blood pressure,
  • depression,
  • nausea,
  • vomiting,
  • bone pain,
  • weakened bones,
  • sleeplessness, and
  • rash.

What is the dosage of anastrozole vs. letrozole?

Anastrozole

The recommended dose of anastrozole is one tablet (1 mg) by mouth once daily.

Letrozole

The recommended dose is 2.5 mg once daily with or without food. Patients with severe liver impairment should receive 2.5 mg every other day.

What drugs interact with anastrozole and letrozole?

Anastrozole

Anastrozole should not be used with tamoxifen because tamoxifen can reduce anastrozole levels in the body and decrease its therapeutic effects. Estrogens decrease the effect of anastrozole by increasing estrogen levels in the body.

Letrozole

Tamoxifen reduces blood levels of letrozole when both drugs are administered together. However, in clinical studies the benefit of letrozole was not reduced when administered immediately after tamoxifen. Letrozole is an anti-estrogen drug. Therefore, estrogen containing products counteract the effect of letrozole.

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