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Amlodipine Besilate + Atenolol

Amlodipine Besilate + Atenolol

Description

Amlodipine ATenolol Tablet is used for Hypertension, Elevated blood pressure, Blood pressure, High blood pressure, Chest pain, Coronary artery disease, Infarction, Chronic stable angina, Vasospastic angina, Myocardial infarction and other conditions. Amlodipine ATenolol Tablet may also be used for purposes not listed in this medication guide.

Amlodipine ATenolol Tablet contains Amlodipine and Atenolol as active ingredients.

Amlodipine ATenolol Tablet works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscles; blocking receptors resulting in slowing of heart rate and reducing oxygen demand;

Jan Aushadhi manufactures Amlodipine ATenolol Tablet.

Uses

Atenolol is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat chest pain (angina) and to improve survival after a heart attack.

Atenolol belongs to a class of drugs known as beta blockers. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart.

Mechanism of Action of Amlodipine 5mg + Atenolol 50mg:

Atenolol Is A Cardioselective Beta Blocker. Amlodipine Is A Dihydropyridine Calcium-Channel Blocker That Blocks The Transmembrane Influx Of Calcium Ions Into Vascular Smooth Muscle And Cardiac Muscle. Combination Of The Two Drugs Results In Additive Antihypertensive Action. Absorption: Amlodipine: Plasma Levels Peak 6-12 Hr After Oral Admin; Absolute Bioavailability Is Estimated To Be 64-90%. Atenolol: Absorption Is Rapid And Consistent But Incomplete; About 50% Of An Oral Dose Is Absorbed In The GI Tract; Plasma Levels Peak 2-4 Hr After Oral Admin.

Distribution: Amlodipine: 93% Bound To Plasma Proteins. Atenolol: 6-16% Bound To Plasma Proteins. Metabolism: Amlodipine: About 90% Converted To Inactive Metabolites Hepatically. Atenolol: Little Or No Hepatic Metabolism. Excretion: Amlodipine: 10% Of Parent Compound And 60% Of The Metabolites Are Removed In The Urine; Elimination From The Plasma Is Biphasic With Terminal Half-Life Of About 30-50 Hr. Atenolol: 50% Of The Oral Dose Is Removed Unchanged In The Faeces; Absorbed Drug Is Removed Mainly Via Renal Elimination; Half-Life Is About 6-7 Hr.

Drug Interactions of Amlodipine 5mg + Atenolol 50mg:

Additive Effect When Used With Catecholamine Depleting Drugs; Monitor For Hypotension And/Or Marked Bradycardia. If Used With Clonidine, Clonidine Withdrawal Should Occur A Few Days After Withdrawal Of The Beta-Blocker To Prevent Rebound Hypertension; If Replacing Clonidine By Beta-Blocker, Beta-Blocker Should Be Introduced Only After Clonidine Administration Has Stopped For Several Days. Concurrent Use With Prostaglandin Synthase Inhibiting Drugs (E.G. Indomethacin) May Reduce The Hypotensive Effects Of Beta-Blockers.

Amlodipine ATenolol Tablet Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Amlodipine ATenolol Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

  • Leg pain
  • Depression
  • Swelling of legs and feet
  • Drowsiness
  • Nausea
  • Stomach pain
  • Dizziness
  • Flushing
  • Arrhythmia
  • Rapid heartbeat

Precautions

Before taking atenolol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as slow heartbeat, second- or third-degree atrioventricular block), breathing problems (such as asthma, chronic bronchitis, emphysema), blood circulation problems (such as Raynaud's disease, peripheral vascular disease), kidney disease, serious allergic reactions including those needing treatment with epinephrine, a certain muscle disease (myasthenia gravis).

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

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