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Amikacin Sulphate

Amikacin Sulphate


Amikacin Sulphate 500 MG Injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci, Enterococci, etc. This medicine is known to cause serious kidney problems and hearing problems, especially in the elderly population. Hence, it should be used with extreme caution in elderly patients as well as in patients with kidney diseases.

Uses of Amikacin Sulphate 500 MG Injection

Intra-abdominal Infection

This medicine is used in the treatment of intra-abdominal infections such as peritonitis, appendicitis, intra-abdominal abscess, etc. caused by bacteria such as E.coli, Streptococci, Enterococci, etc.


This medicine is used in the treatment of pneumonia, which is a common type of lung infection caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, etc.


This medicine is used in the treatment of bacteremia, which is an infection of the blood caused by Staphylococci, Streptococcus pyogenes, etc.

Bone and Joint infections

This medicine is used in the treatment of bone and joint infections such as septic arthritis, osteomyelitis, etc. caused by Staphylococci and Streptococci species.

How should this medicine be used?

Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). When amikacin is injected intravenously, it is usually infused (injected slowly) over a period of 30 to 60 minutes. The length of your treatment depends on the type of infection you have.

You may receive amikacin injection in a hospital or you may administer the medication at home. If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

Side effects

  • Major & minor side effects for Amikacin Sulphate 500 MG Injection
  • Black or tarry stools
  • Blurred vision
  • Decrease in frequency of urination
  • Dizziness
  • Difficulty in breathing
  • Hearing loss
  • Muscle pain
  • Unusual tiredness and weakness
  • Skin Rash
  • Vomiting


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications that may affect the kidneys or hearing may increase the risk of kidney damage or hearing loss if taken with amikacin. Some examples include: amphotericin B, cidofovir, cisplatin, polymyxin B, tobramycin, cephalosporins such as cephaloridine, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, among others.


Before using amikacin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as gentamicin, tobramycin); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: cystic fibrosis, hearing problems (including deafness, decreased hearing), kidney problems, low blood minerals (including potassium, magnesium, calcium), myasthenia gravis, Parkinson's disease.