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All -Trans Retinoic Acid

All -Trans Retinoic Acid

Tretinoin, also known as all-trans retinoic acid (ATRA), is medication used for the treatment of acne and acute promyelocytic leukemia. For acne, it is applied to the skin as a cream or ointment. For leukemia, it is taken by mouth for up to three months

Tretinoin was patented in 1957 and approved for medical use in 1962.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.Tretinoin is available as a generic medication.

What are Retin-A and Retinol Used For?

Both tretinoin and retinol stimulate epidermal turnover. It causes skin to rapidly exfoliate and make new, brighter skin while stimulating collagen and elastin. The result can be smoother, thicker skin with fewer imperfections, such as sun spots.

One of the most exciting benefits can be softer lines and wrinkles, as well as less acne or acne scarring.

Mechanism of action

For its use in cancer, its mechanism of action is unknown, but on a cellular level, laboratory test show that tretinoin forces APL cells to differentiate and stops them from proliferating; in people there is evidence that it forces the primary cancerous promyelocytes to differentiate into their final form, allowing normal cells to take over the bone marrow.

For its use in acne, the mechanism is unknown, but again on a cellular level there is evidence that it decreases the ability of epithelial cells in hair follicles to stick together, leading to fewer blackheads; it also seems to make the epithelial cells divide faster, causing the blackheads to be pushed out.

How Tretinoin Is Given:

Tretinoin is given by mouth (in capsule form).

One size capsule - 10mg, do not crush, chew or dissolve capsules. Protect from light.

Take tretinoin with food.

It also is used as a lotion (topical) for patients with acne and certain rashes.

The amount of tretinoin you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.

Who Can Use Retin-A or Retinol?

Almost anyone can benefit from one of these products. However, they can tend to be a bit irritating to skin, causing dryness or peeling. Keep in mind that the side effects of irritated skin will subside after a few weeks once your skin has adjusted to the product and increased its cell turnover rate.

The benefits of these products can be great, although they may not be suitable for everyone. It is always best to consult with a qualified professional to see how to use these products and which is most suitable for you.

What’s Special About Tretinoin?

Tretinoin is an acid form of vitamin A. When it is delivered to the skin in a gel, it stimulates normal maturation of cells in the epidermis of the skin. Right as it does, it activates genes that cause them to live out a 21-day life cycle during which they are pushed to the surface of the skin. Assuming the problem in the skin was sluggish growth that kept pores tight and tough skin locked over blackheads, nodules, and cysts, stimulating the growth of the skin can be just the thing for hard-to-treat blackheads and small cysts.


Before you start using Tretinoin, you have to take extra care since it may not be suitable for people who have certain conditions. Don’t use Tretinoin without your doctor’s advice if:

You are breastfeeding

You are pregnant or you are actively trying to get pregnant. The drug may get absorbed in your skin and harm your unborn baby.

You have other skin care problems, such as eczema or rosacea

You had skin cancer before or if any of your close family members has had skin cancer

You are on other medication, whether prescribed or not prescribed by a doctor

You reacted allergically to any other medication before, especially Vitamin A related drugs, such as isotretinoin