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Acamprosate Dosage

Acamprosate Dosage

What is acamprosate?

Acamprosate affects chemicals in the brain that may be unbalanced in a person who is addicted to alcohol. Acamprosate works by restoring this chemical balance in the brain in an alcohol-dependent person who has recently quit drinking.

Acamprosate is used together with behavior modification and counseling support to help a person who has recently quit drinking alcohol continue to choose not to drink.

Acamprosate is not likely to be helpful if you have not already quit drinking or undergone detoxification. It may not help you if you are also addicted to other substances besides alcohol.

Acamprosate may also be used for purposes not listed in this medication guide.

Oral dosage

666 mg PO 3 times daily in combination with naltrexone (50 mg PO once daily with food). In a double-blind placebo-controlled trial, 160 patients were randomized to receive naltrexone, acamprosate, naltrexone plus acamprosate, or placebo for 12 weeks. All therapies were significantly more efficacious than placebo with regard to the primary outcomes of time to first drink, time to relapse, and cumulative abstinence.

The naltrexone group tended to have a better outcome of time to first drink and time to relapse when directly compared to acamprosate. The combination of naltrexone and acamprosate demonstrated significantly lower relapse rates than placebo and acamprosate but not naltrexone. Patients received psychotherapy and psychopathologic assessments weekly throughout the treatment phase of the study.

666 mg PO 3 times daily is the suggested dosage. A lower dose may be effective in some patients. Lower initial doses may be required in geriatric adults since renal function may be diminished. Alternative dosage regimens have been used. In one study, doses of 1332 mg/day PO (666 mg in the morning, 333 mg at mid-day, and 333 mg in the evening)

 were administered for patients 60 kg or less, and doses of 1998 mg/day PO (666 mg PO 3 times daily) were administered for patients more than 60 kg. Efficacy in promoting abstinence has not been demonstrated in patients who have not undergone detoxification or achieved alcohol abstinence; therefore, acamprosate is indicated only in patients who are abstinent at the time of treatment initiation. Maintain treatment even if the patient relapses. Pharmacotherapy should be used as a part of a comprehensive management program that includes psychosocial support and treatment.

Dosing Considerations

Hepatic Impairment

Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.

Renal Impairment

CrCl > 50 mL/min: No dosage adjustment necessary.

CrCl 30—50 mL/min: A starting dose of 333 mg PO three times daily is recommended.

CrCl < 30 mL/min: Use is contraindicated.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Start taking acamprosate as soon as possible after you have quit drinking.

You may take acamprosate with or without food.

Do not crush, chew, or break a delayed-release tablet. Swallow it whole.

Take this medicine for the full prescribed length of time, even if you relapse and drink alcohol. While you are taking acamprosate, tell your doctor about any alcoholic drinks you consume, no matter how many.

Use acamprosate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Acamprosate is only part of a complete program of treatment that also includes counseling support and continued abstinence from alcohol.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Acute overdose is usually mild. In the reported cases, the only symptom which can be reasonably related to overdose is diarrhoea. No case of hypercalcaemia has ever been reported. Treatment of overdose is directed to symptoms.

The recommended dose of Campral is two 333 mg tablets (each dose should total 666 mg) taken three Sections or subsections omitted from the full prescribing information are not listed. times daily. A lower dose may be effective in some patients.

Although dosing may be done without regard to meals, dosing with meals was employed during clinical trials and is suggested in those patients who regularly eat three meals daily.

Treatment with Campral should be initiated as soon as possible after the period of alcohol withdrawal, when the patient has achieved abstinence, and should be maintained if the patient relapses. Campral should be used as part of a comprehensive psychosocial treatment program.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • how you respond to this medication
  • your kidney function

The recommended dose of acamprosate  is two 333 mg tablets (each dose should total 666 mg) taken three times daily. A lower dose may be effective in some patients.

The recommended dose of acamprosate (Campral), for patients with moderate renal impairment, is one 333 mg tablet taken three times daily.

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